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The overall goal of this work is to develop and test methods for quantitatively describing the subcellular localization of proteins. More specifically: Is it possible to numerically describe protein localization patterns in cultured eukaryotic cells in a way that is biologically useful? In terms of addressing the issue of `biologically useful', criteria to be considered include the following: Can major classes of localization patterns (e.g., organelles) be distinguished based on the descriptions? How visually subtle can differences between patterns be such that the descriptions are still able to facilitate a distinction? The work described below addresses these questions by using techniques from the fields of fluorescence microscopy and pattern recognition.

Copyright ©1999 Michael V. Boland