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ad hoc Features

To address the concern that the Zernike and Haralick features were not interpretable, a new set of features was developed. The motivation for these ad hoc features was to capture some of the criteria used by biologists to describe the localization of proteins. Some terms frequently used to describe the localization of a protein include punctate, peri-nuclear, cytoplasmic, nuclear, and diffuse. The features designed to capture such information are described in detail in Section 3.2.5. Briefly, however, these features include measures of object distances from the center of the cell, the distribution of object sizes, the degree to which the protein distribution overlaps the nucleus, the diffuseness of the localization pattern, the edge content of the image, the distance of the localization pattern from the nucleus, and others. To help provide some standardization between cells, which are inherently heterogeneous in terms of morphology, some features were designed to take advantage of the DNA image collected along with each protein localization image. The intent was to use the DNA pattern, which is fairly consistent among cells, as a common landmark to which the protein localization pattern could be referred.


next up previous contents
Next: Classification with All Features Up: Feature Extraction Previous: Zernike and Haralick Features
Copyright ©1999 Michael V. Boland
1999-09-18