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 Carnegie Mellon University
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Robert F. Murphy's Research Publications

BOOKS

  1. Applications of Fluorescence in the Biomedical Sciences (1986) D. L. Taylor, A. S. Waggoner, R. F. Murphy, F. Lanni, R. Birge (eds.), Alan R. Liss, Inc., New York.

  2. Endosomes and Lysosomes: A Dynamic Relationship (1993) B. Storrie and R. F. Murphy (eds.), JAI Press.

PUBLICATIONS

  1. R. F. Murphy and J. Bonner (1975). Alkaline Extraction of Non-Histone Proteins from Rat Liver Chromatin. Biochim. Biophys. Acta 405:62-66.

  2. J. M. Gottesfeld, R. F. Murphy and J. Bonner (1975). Structure of Transcriptionally Active Chromatin. Proc. Natl. Acad. Sci. USA 72:4404-4408.

  3. R. B. Wallace, T. D. Sargent, R. F. Murphy and J. Bonner (1977). Physical Properties of Chemically Acetylated Rat Liver Chromatin. Proc. Natl. Acad. Sci. USA 74:3244-3248.

  4. J. Bonner, R. B. Wallace, T. D. Sargent, R. F. Murphy and S. K. Dube (1977). The Expressed Portion of Eukaryotic Chromatin. Cold Spring Harbor Symp. Quant. Biol. 42:851-857.

  5. R. F. Murphy, R. B. Wallace and J. Bonner (1978). Altered Nucleosome Spacing in Newly Replicated Chromatin from Friend Leukemia Cells. Proc. Natl. Acad. Sci. USA 75:5903-5907.

  6. R. B. Wallace, J. Schaeffer, R. F. Murphy, T. Hirosa, K. Itakura and J. Bonner (1979). Hybridization of Synthetic Oligodeoxyribonucleotides to fX174 DNA: The Effect of Single Base Pair Mismatch. Nucleic Acids Res. 6:3543-3557.

  7. R. F. Murphy, W. R. Pearson and J. Bonner (1979). Computer Programs for Analysis of Nucleic Acid Hybridization, Thermal Denaturation and Gel Electrophoresis Data. Nucleic Acids Res. 6:3911-3921.

  8. R. F. Murphy, R. B. Wallace and J. Bonner (1980). Isolation of Newly-Replicated Chromatin by Using Shallow Metrizamide Gradients. Proc. Natl. Acad. Sci. USA 77:3336-3340.

  9. R. F. Murphy (1980). Chromosomal Protein-DNA Interactions. Doctoral Thesis. California Institute of Technology.

  10. R. F. Murphy, J. R. Daban and C. R. Cantor (1981). Flow Cytofluorometric Analysis of the Nuclear Division Cycle of Physarum Polycephalum Plasmodia. Cytometry 2:26-30.

  11. R. F. Murphy, E. D. Jorgensen and C. R. Cantor (1982). Kinetics of Histone Endocytosis in Chinese Hamster Ovary Cells: A Flow Cytofluorometric Analysis. J. Biol. Chem. 257:1695-1701.

  12. R. F. Murphy, S. Powers, M. Vderame, C. R. Cantor and R. Pollack (1982). Flow Cytofluorometric Analysis of Insulin Binding and Internalization by Swiss 3T3 Cells. Cytometry 2:402-406.

  13. R. Haas, R. F. Murphy and C. R. Cantor (1982). Testing Models of the Arrangement of DNA Inside Bacteriophage Lambda by Crosslinking the Packaged DNA. J. Mol. Biol. 159:71-92.

  14. P. L. McNeil, R. F. Murphy, F. Lanni and D. L. Taylor (1984). A Method for Incorporating Macromolecules into Adherent Cells. J. Cell Biol. 98:1556-1564.

  15. R. F. Murphy, S. Powers and C. R. Cantor (1984). Endosome pH Measured in Single Cells by Dual Fluorescence Flow Cytometry: Rapid Acidification of Insulin to pH 6. J. Cell Biol. 98:1757-1762.

  16. R. F. Murphy, S. Powers, C. R. Cantor and R. Pollack (1984). Reduced Insulin Endocytosis in Serum Transformed Fibroblasts Demonstrated by Flow Cytometry. Cytometry 5:275-280.

  17. W. Hiddemann, J. Schumann, M. Andreeff, B. Barlogie, C. J. Herman, R. C. Leif, B. H. Mayall, R. F. Murphy, A. A. Sandberg (1984). Convention on Nomenclature for DNA Cytometry. Cytometry 5:445-446.

  18. R. F. Murphy and T. M. Chused (1984). A Proposal for a Flow Cytometric Data File Standard. Cytometry 5:553-555.

  19. R. F. Murphy, D. B. Tse, C. R. Cantor and B. Pernis (1984). Acidification of Internalized Class I MHC Antigen by T Lymphoblasts. Cell. Immunol. 88:336-342.

  20. R. F. Murphy, E. Bisaccia, C. R. Cantor, C. Berger and R. L. Edelson (1984). Internalization and Acidification of Insulin by Activated Human Lymphocytes. J. Cell. Physiol. 121:351-356.

  21. P. L. Wollenzien, C. F. Hui, C. Kang, R. F. Murphy and C. R. Cantor (1984) RNA structure, Free and on the Ribosome, as Revealed by Chemical and Enzymatic Studies. In: Mechanisms of Protein Synthesis, Bermek, (ed.), Springer-Verlag, Berlin.

  22. P. L. McNeil, A. L. Kennedy, A. S. Waggoner, D. L. Taylor and R. F. Murphy (1985). Light Scattering Changes During Chemotactic Stimulation of Human Neutrophils: Kinetics Followed by Flow Cytometry. Cytometry 6:7-12.

  23. R. F. Murphy (1985). Automatic Identification of Subpopulations in Flow Cytometric List Mode Data Using Cluster Analysis. Cytometry 6:302-309.

  24. P. L. Wollenzien, R. F. Murphy, C. R. Cantor, A. Expert-Bezancon and D. H. Hayes (1985). Structure of the E. coli 16S rRNA. Psoralen Crosslinks and N-Acetyl-N'-(p-Glyoxylylbenzoyl) Cystamine Crosslinks Detected by Electron Microscopy. J. Mol. Biol. 184:67-80.

  25. C. R. Cantor, D. B. Tse, J. McDowell, R. Murphy, and B. Pernis (1985). Internalization of Histocompatibility Antigens Studied by Flow Cytometry. In: Cell Biology of the Major Histocompatibility Complex, B. Pernis & H. J. Vogel (eds.), Academic Press, New York, pp. 165-172.

  26. R. F. Murphy (1985). Analysis and Isolation of Endocytic Vesicles by Flow Cytometry and Sorting: Demonstration of Three Kinetically Distinct Compartments Involved in Fluid-Phase Endocytosis. Proc. Natl. Acad. Sci. USA 82:8523-8526.

  27. M. Fechheimer, C. Denny, R. F. Murphy, and D. L. Taylor (1986).Measurement of cytoplasmic pH in Dictyostelium discoideum by using a new method for introducing macromolecules into living cells. Eur. J. Cell Biol. 40:242-247.

  28. R. F. Murphy (1986). Flow Cytometry in Cell Biology. In: Applications of Fluorescence in the Biomedical Sciences, D. L. Taylor, A. S. Waggoner, R. F. Murphy, F. Lanni, R. Birge (eds.), Alan R. Liss, Inc., New York, pp. 525-530.

  29. R. F. Murphy and M. Roederer (1986). Flow Cytometric Analysis of Endocytic Pathways. In: Applications of Fluorescence in the Biomedical Sciences, D. L. Taylor, A. S. Waggoner, R. F. Murphy, F. Lanni, R. Birge (eds.), Alan R. Liss, Inc., New York, pp. 545-566.

  30. C. C. Cain and R. F. Murphy (1986). Growth Inhibition of 3T3 Fibroblasts by Lysosomotropic Amines: Correlation with Effects on Intravesicular pH but Not Vacuolation. J. Cell. Physiol. 129:65-70.

  31. M. Roederer and R. F. Murphy (1986). Cell-By-Cell Autofluorescence Correction for Low Signal-to-Noise Systems: Application to EGF Endocytosis by 3T3 Fibroblasts. Cytometry 7:558-565.

  32. M. Roederer, R. Bowser, and R. F. Murphy (1987). Kinetics and Temperature Dependence of Exposure of Endocytosed Material to Proteolytic Enzymes and Low pH: Evidence for a Maturation Model for the Formation of Lysosomes. J. Cell. Physiol. 131:200-209.

  33. S. Taylor, M. Roederer, and R. F. Murphy (1987). Flow Cytometric DNA Analysis of Adrenocortical Tumors in Children. Cancer 59:2059-2063.

  34. D. M. Sipe and R. F. Murphy (1987). High resolution kinetics of transferrin acidification in Balb/c 3T3 cells: Exposure to pH 6 followed by temperature-sensitive alkalinization during recycling. Proc. Natl. Acad. Sci. USA 84:7119-7123.

  35. R. A. Preston, R. F. Murphy, and E. W. Jones (1987). Apparent Endocytosis of FITC-Dextran by Saccharomyces cerevisiae Reflects Uptake of Low Molecular Weight Impurities, not Dextran. J. Cell Biol. 105:1981-1987.

  36. C. C. Cain and R. F. Murphy (1988). A Chloroquine-resistant Swiss 3T3 Cell Line with a Defect in Late Endocytic Acidification. J. Cell Biol. 106:269-277.

  37. S. Taylor, J. Blatt, J. Costantino, M. Roederer, and R. F. Murphy (1988). Flow Cytometric DNA Analysis of Neuroblastoma and Ganglioneuroma: a 10-year Retrospective Study. Cancer 62:749-754.

  38. R. F. Murphy (1988). Processing of Endocytosed Material. Adv. Cell Biol. 2:159-180.

  39. C. C. Cain, D. M. Sipe and R. F. Murphy (1989). Regulation of Endocytic pH by the Na+ /K+-ATPase in Living Cells. Proc. Natl. Acad. Sci. USA 86:544-548.

  40. M. Roederer, R. W. Mays and R. F. Murphy (1989). Effect of Confluence on Endocytosis by 3T3 Fibroblasts: Increased Rate of Pinocytosis and Accumulation of Residual Bodies. Eur. J. Cell Biol. 48:37-44.

  41. C. R. Abramowsky, S. R. Taylor, A. H. Anton, A. Berk, M. Roederer and R. F. Murphy (1989). Flow Cytometry DNA Ploidy Analysis and Catecholamine Secretion Profiles in Neuroblastoma. Cancer 63:1752-1756.

  42. R. B. Wilson and R. F. Murphy (1989). Flow Cytometric Analysis of Endocytic Compartments. Methods Cell Biol. 31:293-317.

  43. R. F. Murphy (1989). Flow Cytometric Analysis of Ligand Binding and Endocytosis. In: Microspectrofluorometry of Single Cells, E. Kohen and J. G. Hirschberg (eds.), Academic Press, New York, pp. 363-376.

  44. R. F. Murphy, M. Roederer, D. M. Sipe, C. Cain, and R. Bowser (1989). Determination of the Biochemical Characteristics of Endocytic Compartments by Flow Cytometric and Fluorometric Analysis of Cells and Organelles. In: Flow Cytometry: Advanced Research and Clinical Applications, Volume II, A. Yen (ed.), CRC Press, Boca Raton, FL, pp. 221-254.

  45. R. A. Preston, R. F. Murphy and E. W. Jones (1989). Assay of Vacuolar pH in Yeast and Identification of Acidification-defective Mutants. Proc. Natl. Acad. Sci. USA 86:7027-7031.

  46. R. F. Murphy (1990). Ligand Binding, Endocytosis, and Processing. In: Flow Cytometry and Sorting, Second Edition, M. R. Melamed, T. Lindmo, M. L. Mendelsohn (eds.), Wiley-Liss, Inc., New York, pp. 355-366.

  47. R. Bowser and R. F. Murphy (1990). Kinetics of Hydrolysis of Endocytosed Substrates by Mammalian Cultured Cells: Early Introduction of Lysosomal Enzymes into the Endocytic Pathway. J. Cell. Physiol. 143:110-117.

  48. M. Roederer, J. Barry, R. B. Wilson and R. F. Murphy (1990). Endosomes Can Undergo an ATP-dependent Density Increase in the Absence of Dense Lysosomes. Eur. J. Cell Biol. 51:229-234.

  49. P. N. Dean, C. B. Bagwell, T. Lindmo, R. F. Murphy, and G. C. Salzman (1990). Data File Standard for Flow Cytometry. Cytometry 11:323-332.

  50. D. M. Sipe, A. Jesurum and R. F. Murphy (1991). Absence of Na+,K+-ATPase Regulation of Endosomal pH in K562 Erythroleukemia Cells: Analysis via Inhibition of Transferrin Recycling by Low Temperatures. J. Biol. Chem. 266:3469-3474.

  51. D. M. Sipe and R. F. Murphy (1991). Binding to Cellular Receptors Results in Increased Iron Release from Transferrin at Mildly Acidic pH. J. Biol. Chem. 266:8002-8007. [Copy as Word 97/98 document: high-resolution (1.5 MB) low-resolution (856 KB)]

  52. C. C. Cain, R. B. Wilson and R. F. Murphy (1991). Isolation by Fluorescence-Activated Cell Sorting of Chinese Hamster Ovary Cell Lines with Pleiotropic, Temperature-Conditional Defects in Receptor Recycling. J. Biol. Chem. 266:11746-11752.

  53. R. F. Murphy (1991). Maturation Models for Endosome and Lysosome Biogenesis. Trends Cell Biol. 1:77-82.

  54. R. F. Murphy, M. Roederer, D. M. Sipe, C. C. Cain and R. B. Wilson (1992). Endosomal pH Regulation and the Maturation Model for Lysosome Biogenesis. In: Endocytosis: From Cell Biology to Health, Disease and Therapy (Proceedings of the NATO Advanced Research Workshop on Endocytosis), P. J. Courtoy (ed.), NATO ASI Series H, Vol. 62, Springer Verlag, pp. 91-95.

  55. R. E. Valdes-Perez, H. A. Simon, and R. F. Murphy (1992) Discovery of pathways in science. In: Proceedings of the ML92 Workshop on Machine Discovery, J. Zytkow (ed.), Aberdeen, Scotland, pp. 51-57.

  56. R. F. Murphy (1992) Scatchard analysis by flow cytometry. In: Flow Cytometry and Cell Sorting, A. Radbruch (ed.), Springer Verlag, Berlin, pp. 59-62.

  57. R. F. Murphy (1992) Ligand acidification by non-adherent cells. In: Flow Cytometry and Cell Sorting, A. Radbruch (ed.), Springer Verlag, Berlin, pp. 124-129.

  58. S. A. Brockman and R. F. Murphy (1993) Endosomal and Lysosomal Hydrolases. In: Biological Barriers to Protein Delivery (Pharmaceutical Biotechnology, Vol. 4), K. L. Audus and T. J. Raub (eds.), Plenum Press, New York, pp. 51-70.

  59. R. F. Murphy (1993) Models of Endosome and Lysosome Traffic. Adv. Cell Mol. Biol. Memb. 1:1-17.

  60. R. F. Murphy, J. Schmid and R. Fuchs (1993) Endosome maturation: Insights from somatic cell genetics and cell-free analysis. Biochem. Soc. Trans. 21:716-720.

  61. R. B. Wilson, C. C. Mastick and R. F. Murphy (1993). A Chinese Hamster Ovary Cell Line with a Temperature-Conditional Defect in Receptor Recycling is Pleiotropically Defective in Lysosome Biogenesis. J. Biol. Chem. 268:25357-25363.

  62. M. Bucci, T. W. Moyer, C. M. Brown, R. B. Wilson and R. F. Murphy (1994). The receptor-recycling and lysosome biogenesis mutant TfT1.11 belongs to a new complementation group, End6. Somatic Cell Mol. Genet. 20:47-54.

  63. S. A. Brockman and R. F. Murphy (1994). Isolation and Analysis of Somatic Cell Mutants with Defects in Endocytic Traffic. Methods Cell Biol. 42:131-148.

  64. L.C. Seamer, C.B. Bagwell, L. Barden, D. Redelman, G.C. Salzman, J.C. Wood, R.F. Murphy (1997). Proposed new data file standard for flow cytometry, version FCS 3.0. Cytometry 28:118-122. [PDF Reprint]

  65. S. L. Rybak, F. Lanni and R. F. Murphy (1997). Theoretical considerations on the role of membrane potential in the regulation of endosomal pH. Biophys. J. 73:674-687. [Article at BJ web site] [Project Description]

  66. M. V. Boland, M. K. Markey and R. F. Murphy (1997) Automated Classification of Cellular Protein Localization Patterns Obtained via Fluorescence Microscopy. Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, pp. 594-597. [Project Description] [PDF Reprint]

  67. M. V. Boland and R. F. Murphy (1998) Multivariate Analysis. In: Current Protocols in Cytometry, pp. 10.8.1-10.8.21.

  68. S. L. Rybak and R. F. Murphy (1998) Primary Cell Cultures from Murine Kidney and Heart Differ in Endosomal pH. J. Cell. Physiol. 176:216-222. [PDF Reprint]

  69. M. V. Boland, M. K. Markey and R. F. Murphy (1998) Automated Recognition of Patterns Characteristic of Subcellular Structures in Fluorescence Microscopy Images. Cytometry 33: 366-375. [Project Description] [Dataset Download] [PDF Reprint]

  70. N. Bayer, D. Schober, E. Prchla, R. F. Murphy, D. Blass, and R. Fuchs (1998) Effect of bafilomycin A1 and nocodazole on endocytic transport in HeLa cells: Implications for viral uncoating and infection. J. Virol. 72: 9645-55. [PDF Reprint]

  71. D. Schober, N. Bayer, R.F. Muphy, E. Wagner, and R. Fuchs (1999). Establishment of an assay to determine adenovirus-induced endosome rupture required for receptor-mediated gene delivery. Gene Therapy Mol. Biol. 3:1-9.

  72. M. K. Markey, M. V. Boland and R. F. Murphy (1999). Towards Objective Selection of Representative Microscope Images. Biophys. J. 76:2230-2237. [Article at BJ web site] [Project Description] [PDF Reprint]

  73. M. V. Boland and R. F. Murphy (1999). Automated analysis of patterns in fluorescence-microscope images. Trends Cell. Biol. 9(5): 201-202. [PDF Reprint]

  74. R. F. Murphy and M. V. Boland (1999). Pattern Analysis Meets Cell Biology. Microsc. Microanal. 5 (Suppl. 2: Proceedings): 510-511.

  75. M. V. Boland and R. F. Murphy (1999). After Sequencing: Quantitative Analysis of Protein Localization. IEEE Eng. Med. Biol. Mag. 18(5): 115-119. [PDF Reprint]

  76. R. F. Murphy (1999). Scatchard analysis by flow cytometry. In: Flow Cytometry and Cell Sorting, 2nd Ed., A. Radbruch (ed.), Springer Verlag, Berlin, pp. 82-85.

  77. R. F. Murphy (1999). Ligand acidification by non-adherent cells. In: Flow Cytometry and Cell Sorting, 2nd Ed., A. Radbruch (ed.), Springer Verlag, Berlin, pp. 186-193.

  78. S. L. Rybak and R. F. Murphy (2000). Measurement of Ligand Acidification Kinetics for Adherent and Non-Adherent Cells. In: In Living Color: Protocols in Flow Cytometry and Cell Sorting (R. Diamond and S. DeMaggio, eds.), pp. 496-523.

  79. R. F. Murphy, M. V. Boland and M. Velliste (2000). Towards a Systematics for Protein Subcellular Location: Quantitative Description of Protein Localization Patterns and Automated Analysis of Fluorescence Microscope Images. Proc Int Conf Intell Syst Mol Biol (ISMB 2000) 8: 251-259. [PDF Reprint with high res images (3.8 MB)] [PDF Reprint with compressed images (176 K)]

  80. R. F. Murphy, M. Velliste, J. Yao, and G. Porreca (2001). Searching Online Journals for Fluorescence Microscope Images Depicting Protein Subcellular Location Patterns. Proc IEEE Int Symp Bio-Informat Biomed Eng (BIBE 2001) 2; pp. 119-128. [PDF Reprint]

  81. M. V. Boland and R. F. Murphy (2001). A Neural Network Classifier Capable of Recognizing the Patterns of all Major Subcellular Structures in Fluorescence Microscope Images of HeLa Cells. Bioinformatics 17:1213-1223. [Article at journal web site] PDF Reprint] [Screen PDF] [Software] [Data]

  82. S.A. Jesch, A.J. Mehta, M. Velliste, R.F. Murphy and A.D. Linstedt (2001). Mitotic Golgi is in a Dynamic Equilibrium Between Clustered and Free Vesicles Independent of the ER. Traffic 2: 873-884. [PDF Reprint]

  83. E.J.S. Roques and R.F. Murphy (2002). Objective evaluation of differences in protein subcellular distribution. Traffic 3: 61-65. [PDF Reprint]

  84. C.A. Telmer, P.B. Berget, B. Ballou, R.F. Murphy, and J.W. Jarvik (2002) Epitope tagging genomic DNA usng a CD-tagging Tn10 Minitransposon. Biotechniques 32: 422-430. [PDF Reprint]

  85. K. Huang, J. Lin, J.A. Gajnak, and R.F. Murphy (2002) Image Content-based Retrieval and Automated Interpretation of Fluorescence Microscope Images via the Protein Subcellular Location Image Database. Proc 2002 IEEE Intl Symp Biomed Imaging (ISBI 2002), pp. 325-328. [PDF Reprint]

  86. M. Velliste and R.F. Murphy (2002) Automated Determination of Protein Subcellular Locations from 3D Fluorescence Microscope Images. Proc 2002 IEEE Intl Symp Biomed Imaging (ISBI 2002), pp. 867-870. [PDF Reprint]

  87. R.F. Murphy, M. Velliste and G. Porreca (2002) Robust Classification of Subcellular Location Patterns in Fluorescence Microscope Images. Proc 2002 IEEE Intl Workshop Neural Networks Signal Processing (NNSP 12), pp. 67-76. [PDF Reprint]

  88. J. H. Price, A. Goodacre, K. Hahn, L. Hodgson, E. A. Hunter, S. Krajewski, R. F. Murphy, A. Rabinovich, J. C. Reed, and S. Heynen (2002) Advances in Molecular Labeling, High Throughput Imaging and Machine Intelligence Portend Powerful Functional Cellular Biochemistry Tools. J. Cell. Biochem. Supp. 39: 194-210. [PDF Reprint]

  89. X. Chen, M. Velliste, S. Weinstein, J.W. Jarvik and R.F. Murphy (2003) Location proteomics - Building subcellular location trees from high resolution 3D fluorescence microscope images of randomly-tagged proteins. Proc. SPIE 4962: 298-306. [PDF Reprint]

  90. K. Huang, M. Velliste, and R. F. Murphy (2003) Feature reduction for improved recognition of subcellular location patterns in fluorescence microscope images. Proc. SPIE 4962: 307-318. [PDF Reprint]

  91. W. W. Cohen, R. Wang, and R. F. Murphy (2003) Understanding Captions in Biomedical Publications. Proceedings of the Ninth ACM SIGKDD International Conference on Knowledge Discovery and Data Mining (KDD-2003), pp. 499-504. [PDF Reprint]

  92. Z. Kou, W. W. Cohen, and R. F. Murphy (2003) Extracting information from text and images for location proteomics. Proceedings of the Third ACM SIGKDD Workshop on Data Mining in Bioinformatics (BIOKDD03) pp. 2-9. [PDF Reprint]

  93. R. F. Murphy, M. Velliste, and G. Porreca (2003) Robust Numerical Features for Description and Classification of Subcellular Location Patterns in Fluorescence Microscope Images. J. VLSI Sig. Proc. 35: 311-321. [PDF Reprint]

  94. S. Puri, H. Telfer, M. Velliste, R.F. Murphy, and A.D. Linstedt (2004). Dispersal of Golgi matrix proteins during mitotic Golgi disassembly. J. Cell Sci. 117:451-456. [Article at JCS web site] [PDF Reprint]

  95. R. F. Murphy (2004) Automated Interpretation of Subcellular Location Patterns. Proc 2004 IEEE Intl Symp Biomed Imaging (ISBI 2004), pp. 53-56. [PDF Reprint]

  96. K. Huang and R. F. Murphy (2004) Automated Classification of Subcellular Patterns in Multicell images without Segmentation into Single Cells. Proc 2004 IEEE Intl Symp Biomed Imaging (ISBI 2004), pp. 1139-1142. [PDF Reprint]

  97. K. Huang and R. F. Murphy (2004) Boosting accuracy of automated classification of fluorescence microscope images for location proteomics. BMC Bioinformatics 5:78. [Article at journal web site] [PDF Reprint]

  98. R. F. Murphy (2004) Automated Interpretation of Protein Subcellular Location Patterns: Implications for Early Cancer Detection and Assessment. Annals of the New York Academy of Science 1020:124-131. [PDF Reprint]

  99. A. K. Singh, B.S. Manjunath, and R. F. Murphy (2004) A Distributed Database for Bio-Molecular Images. SIGMOD Record 33(2). [PDF Reprint]

  100. Y. Hu and R. F. Murphy (2004) Automated Interpretation of Subcellular Patterns from Immunofluorescence Microscopy. J. Immunol. Methods 290:93-105. [PDF Reprint]

  101. R. F. Murphy (2004) Automated Determination of Subcellular Location from Confocal Microscope Images. Microsc. Microanal. 10 (Suppl. 2): 1242-1243. [PDF Reprint]

  102. K. Huang and R. F. Murphy (2004) From Quantitative Microscopy to Automated Image Understanding. J. Biomed. Optics 9: 893-912. [PDF Reprint]

  103. X. Chen and R. F. Murphy (2004) Robust Classification of Subcellular Location Patterns in High Resolution 3D Fluorescence Microscope Images. Proceedings of the 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, pp. 1632-1635. [PDF Reprint]

  104. K. Huang and R. F. Murphy (2004) Data Mining Methods for a Systematics of Protein Subcellular Location. In: Data Mining in Bioinformatics (J.T.L. Wang, M.J. Zaki, H.T.T. Toivonen, and D. Shasha, eds.) , Springer-Verlag (London), pp. 143-187. [Book description at Springer web site]

  105. R. F. Murphy, Z. Kou, J. Hua, M. Joffe, and W. W. Cohen (2004) Extracting and Structuring Subcellular Location Information from On-line Journal Articles: The Subcellular Location Image Finder. Proceedings of the IASTED International Conference on Knowledge Sharing and Collaborative Engineering (KSCE 2004), pp. 109-114. [PDF Reprint]

  106. X. Chen and R. F. Murphy (2004). Location Proteomics: Determing the Optimal Groupings of Proteins according to their Subcellular Location Patterns as determined from Fluorescence Microscope Images. Proceedings of the 38th Asilomar Conference on Signals, Systems and Computers, pp. 50-54.

  107. M. Brabec, D. Schober, E. Wagner, N. Bayer, R.F. Murphy, D. Blaas, and R. Fuchs (2005). Opening of size selective pores in endosomes during human rhinovirus serotype 2 in vivo uncoating monitored by single organelle flow analysis. J. Virol. 79: 1008-1016. [Article at J Virol web site] [PDF Reprint]

  108. X. Chen and R. F. Murphy (2005). Automated interpretation of protein subcellular location. Biophotonics Intl 12(3):34-35.

  109. T.E. Merryman Jr., J. Kovacevic, R. F. Murphy, and E. Garcia Osuna (2005). Adaptive Multirate Data Acquisition of 3D Cell Images. Proceedings of ICASSP 2005, pp. II-133-136. [PDF Reprint]

  110. G. Baravalle, D. Schober, M. Huber, N. Bayer, R.F. Murphy and R. Fuchs (2005). Transferrin recycling and transport to lysosomes is differentially affected by bafilomycin, nocodazole and low temperature. Cell Tissue Res. 320:99-113. [Article at journal web site] [PDF Reprint]

  111. R.F. Murphy (2005). Location Proteomics: A Systems Approach to Subcellular Location. Biochem. Soc. Trans. 33:535-538. [Article at journal web site] [PDF Reprint]

  112. X. Chen and R. F. Murphy (2005). Objective Clustering of Proteins Based on Subcellular Location Patterns. J. Biomed. Biotech. 2005(2):87-95. [Article at journal web site] [PDF Reprint]

  113. Z. Kou, W.W. Cohen and R.F. Murphy (2005). High-recall protein entity recognition using a dictionary. Bioinformatics 21:i266-i273. [Article at journal web site] [PDF Reprint]

  114. P. Nair, B.E. Schaub, K. Huang, X. Chen, R.F. Murphy, J.M. Griffith, H.J. Geuze, and J. Rohrer (2005). Characterization of the TGN Exit Signal of the human Mannose 6-Phosphate Uncovering Enzyme. J. Cell Sci. 118:2949-2956. [Article at journal web site] [PDF Reprint]

  115. R.F. Murphy (2005). Location Proteomics: Providing Critical Information for systems Biology. Bioforum Europe, 2005/04.

  116. R.F. Murphy (2005). Location Proteomics. GIT Imaging & Microscopy, 2005/02.

  117. T. Zhao, M. Velliste, M.V. Boland, and R.F. Murphy (2005). Object Type Recognition for Automated Analysis of Protein Subcellular Location. IEEE Trans. Image Proc. 14:1351-1359 [PDF Reprint]

  118. R.F. Murphy (2005). Cytomics and Location Proteomics: Automated Interpretation of Subcellular Patterns in Fluorescence Microscope Images. Cytometry 67A:1-3 [PDF Reprint]

  119. G. Valet, R.F. Murphy, J.P. Robinson, A. Tarnok and A. Kriete (2006). Cytomics - from cell states to predictive medicine. In: Computational Systems Biology (A. Kriete and R. Eils, eds.), pp. 363-381.

  120. S.-C. Chen and R.F. Murphy (2006). A graphical model approach to automated classification of protein subcellular location patterns in multi-cell images. BMC Bioinformatics 7:90. [Article at journal web site] [PDF Reprint] [Software/Data]

  121. T. Zhao and R.F. Murphy (2006). Automated Interpretation of Subcellular Location Patterns from Three Dimensional Confocal Microscopy. In: Handbook of Biological Confocal Microscopy, Third Edition (J.W. Pawley, ed.), pp. 818-828.

  122. S.-C. Chen, G. Gordon, and R.F. Murphy (2006). A Novel Approximate Inference Approach to Automated Classification of Protein Subcellular Location Patterns in Multi-Cell Images. Proceedings of the 2006 IEEE International Symposium on Biomedical Imaging (ISBI 2006), pp. 558-561. [PDF Reprint] [Software/Data]

  123. T. Zhao, S. Soto, and R.F. Murphy (2006). Improved Comparison of Protein Subcellular Location Patterns. Proceedings of the 2006 IEEE International Symposium on Biomedical Imaging (ISBI 2006), pp. 562-565. [PDF Reprint]

  124. L. Coulot, H. Kirschner, A. Chebira, J.M.F. Moura, J. Kovacevic, E. Garcia Osuna, and R.F. Murphy (2006). Topology Preserving STACS Segmentation of Protein Subcellular Location Images. Proceedings of the 2006 IEEE International Symposium on Biomedical Imaging (ISBI 2006), pp. 566-569. [PDF Reprint]

  125. Y. Hu, J. Carmona, and R.F. Murphy (2006). Application of Temporal Texture Features to Automated Analysis of Protein Subcellular Locations in Time Series Fluorescence Microscope Images. Proceedings of the 2006 IEEE International Symposium on Biomedical Imaging (ISBI 2006), pp. 1028-1031. [PDF Reprint]

  126. X. Chen, and R.F. Murphy (2006). Automated Interpretation of Protein Subcellular Location Patterns. International Review of Cytology 249:193-227. [PDF Reprint]

  127. X. Chen, M. Velliste, and R.F. Murphy (2006). Automated Interpretation of Subcellular Patterns in Fluorescence Microscope Images for Location Proteomics. Cytometry 69A:631-640. [PDF Reprint]

  128. Y.-L. Wang, K.M. Hahn, R.F. Murphy, and A.F. Horwitz (2006). From imaging to understanding: Frontiers in Live Cell Imaging, Bethesda, MD April 19-21, 2006 [Meeting Review]. J. Cell. Biol. 174:1-4. [PDF Reprint]

  129. R.F. Murphy (2006). Putting proteins on the map [News and Views]. Nature Biotech. 24:1223-1224. [PDF Reprint]

  130. S.-C. Chen, T. Zhao, G.J. Gordon and R.F. Murphy (2006). A Novel Graphical Model Approach to Segmenting Cell Images. Proceedings of the 2006 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB '06), pp. 1-8. [PDF Reprint]

  131. Z. Kou, W. W. Cohen, and R.F. Murphy (2007). A Stacked Graphical Model for Associating Information from Text and Images in Figures. Pacific Symposium on Biocomputing 12:257-268. [Article at conference web site] [PDF Reprint]

  132. E. Glory and R.F. Murphy (2007). Automated Subcellular Location Determination and High Throughput Microscopy. Developmental Cell 12:7-16. [Article at journal web site] [Email Dr. Murphy to request PDF]

  133. X. Chen and R. F. Murphy (2007). Interpretation of Protein Subcellular Location Patterns in 3D Images Across Cell Types and Resolutions. Lectures Notes in Bioinformatics 4414:328-342. [PDF Reprint]

  134. R.F. Murphy (2007). Systematic Description Of Subcellular Location For Integration With Proteomics Databases And Systems Biology Modeling. Proceedings of the 2007 IEEE International Symposium on Biomedical Imaging (ISBI 2007), pp. 1052-1055. [PDF Reprint]

  135. J. Hua, O.N. Ayasli, W.W. Cohen, and R.F. Murphy (2007). Identifying Fluorescence Microscope Images in Online Journal Articles Using Both Image and Text Features. Proceedings of the 2007 IEEE International Symposium on Biomedical Imaging (ISBI 2007), pp. 1224-1227. [PDF Reprint]

  136. E. Garcia Osuna, J. Hua, N.W. Bateman, T. Zhao, P.B. Berget and R.F. Murphy (2007). Large-Scale Automated Analysis of Location Patterns in Randomly Tagged 3T3 Cells. Annals Biomed. Eng. 35:1081-1087. [PDF Reprint]

  137. A. Chebira, Y. Barbotin, C. Jackson, T. Merryman, G. Srinivasa, R.F. Murphy, and J. Kovacevic (2007). A multiresolution approach to automated classification of protein subcellular location images. BMC Bioinformatics 8:210. [Article at journal web site] [PDF Reprint]

  138. T. Zhao, S.-C. Chen, and R. F. Murphy (2007). Location Proteomics. In: Introduction to Systems Biology. (S. Choi, ed.), Humana Press, pp. 196-214.

  139. S.-C. Chen, T. Zhao, G. J. Gordon, and R. F. Murphy (2007). Automated Image Analysis of Protein Localization in Budding Yeast. Bioinformatics 23:i66-i71. [Article at journal web site] [PDF Reprint] [Software/Data]

  140. E. Garcia Osuna and R.F. Murphy (2007). Automated, Systematic Determination of Protein Subcellular Location using Fluorescence Microscopy. In: Subcellular Proteomics: From Cell Deconstruction to System Reconstruction (E. Bertrand and M. Faupel, eds.), Springer, pp. 263-278.

  141. C. Jackson, R.F. Murphy and J. Kovacevic (2007). Efficient Acquisition and Learning of Fluorescence Microscopy Data Models. Proceedings of 2007 IEEE International Conference on Image Processing.

  142. T. Zhao and R. F. Murphy (2007). Automated learning of generative models for subcellular location: Building blocks for systems biology. Cytometry 71A:978-990. [Article at journal web site] [PDF Reprint] [Software/Data]

  143. Y. Qian and R.F. Murphy (2008). Improved Recognition of Figures containing Fluorescence Microscope Images in Online Journal Articles using Graphical Models. Bioinformatics 24:569-576. [Article at journal web site] [PDF Reprint]

  144. G. K. Rohde, A. Ribeiro, K. N. Dahl, and R. F. Murphy (2008). Deformation-based nuclear morphometry: capturing nuclear shape variation in HeLa Cells. Cytometry 73A:341-350. [Article at journal web site] [PDF Reprint]

  145. S.-C. Chen, G. J. Gordon, and R.F. Murphy (2008). Graphical Models for Structured Classification, with an Application to Interpreting Images of Protein Subcellular Location Patterns. J. Machine Learning Res. 9, in press. [Article at journal web site] [PDF Reprint]

  146. J. Newberg and R. F. Murphy (2008). A Framework for the Automated Analysis of Subcellular Patterns in Human Protein Atlas Images. J. Proteome Res. 9, in press. [Article at journal web site] [ASAP PDF Reprint]


Last Updated: 02 May 2008




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